Dataset Information
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000426 | EGA |
REPOSITORIES: EGA
Publications
Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes.
Scientific reports 20160720
Current therapies for metastatic clear cell renal cell carcinoma (ccRCC) show limited efficacy. Drug efficacy, typically investigated in preclinical cell line models during drug development, is influenced by pharmacogenes involved in targeting and disposition of drugs. Here we show through genome-wide DNA methylation profiling, that methylation patterns are concordant between primary ccRCC and macro-metastases irrespective of metastatic sites (rs ≥ 0.92). However, 195,038 (41%) of all investigat ...[more]
