Dataset Information
Charité Universitätsmedizin Berlin
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000581 | EGA |
REPOSITORIES: EGA
Publications
Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.
Molecular cancer research : MCR 20170201 5
Promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is a critical biomarker in glioblastoma (GBM), as treatment decisions and clinical trial inclusion rely on its accurate assessment. However, interpretation of results is complicated by poor interassay reproducibility as well as a weak correlation between methylation status and expression levels of MGMT. This study systematically investigates the influence of tumor purity on tissue subjected to MGM ...[more]