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Omics score: 1000

Institute for Molecular Medicine Finland, University of Helsinki

ABSTRACT: Organisation EGAO00000000684

PROVIDER: EGAO00000000684 | EGA |

REPOSITORIES: EGA

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Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.

Saeed Khalid K Rahkama Vesa V Eldfors Samuli S Bychkov Dmitry D Mpindi John Patrick JP Yadav Bhagwan B Paavolainen Lassi L Aittokallio Tero T Heckman Caroline C Wennerberg Krister K Peehl Donna M DM Horvath Peter P Mirtti Tuomas T Rannikko Antti A Kallioniemi Olli O Östling Päivi P Af Hällström Taija M TM

European urology 20160506 3

<h4>Background</h4>Technology development to enable the culture of human prostate cancer (PCa) progenitor cells is required for the identification of new, potentially curative therapies for PCa.<h4>Objective</h4>We established and characterized patient-derived conditionally reprogrammed cells (CRCs) to assess their biological properties and to apply these to test the efficacies of drugs.<h4>Design, setting, and participants</h4>CRCs were established from seven patient samples with disease rangin ...[more]

PMID: 27160946

Publication: 1/2

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Institute of biomedicine, School of medicine, University of Eastern Finland

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SARS-CoV-2 infections among healthcare workers at Helsinki University Hospital, Finland, spring 2020: Serosurvey, symptoms and risk factors.

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Project description:Organisation EGAO00000000729

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Heat, Heatwaves and Cardiorespiratory Hospital Admissions in Helsinki, Finland.

Project description:Background: There is a lack of knowledge concerning the effects of ambient heat exposure on morbidity in Northern Europe. Therefore, this study aimed to evaluate the relationships of daily summertime temperature and heatwaves with cardiorespiratory hospital admissions in the Helsinki metropolitan area, Finland. Methods: Time series models adjusted for potential confounders, such as air pollution, were used to investigate the associations of daily temperature and heatwaves with cause-specific cardiorespiratory hospital admissions during summer months of 2001-2017. Daily number of hospitalizations was obtained from the national hospital discharge register and weather information from the Finnish Meteorological Institute. Results: Increased daily temperature was associated with a decreased risk of total respiratory hospital admissions and asthma. Heatwave days were associated with 20.5% (95% CI: 6.9, 35.9) increased risk of pneumonia admissions and during long or intense heatwaves also with total respiratory admissions in the oldest age group (≥75 years). There were also suggestive positive associations between heatwave days and admissions due to myocardial infarction and cerebrovascular diseases. In contrast, risk of arrhythmia admissions decreased 20.8% (95% CI: 8.0, 31.8) during heatwaves. Conclusions: Heatwaves, rather than single hot days, are a health threat affecting morbidity even in a Northern climate.

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Beijing Institute of Radiation Medicine Enterovirus Protein Array

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