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University of Copenhagen

ABSTRACT: Organisation EGAO00000000727

PROVIDER: EGAO00000000727 | EGA |

REPOSITORIES: EGA

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Publications

A genomic history of Aboriginal Australia.

Malaspinas Anna-Sapfo AS Westaway Michael C MC Muller Craig C Sousa Vitor C VC Lao Oscar O Alves Isabel I Bergström Anders A Athanasiadis Georgios G Cheng Jade Y JY Crawford Jacob E JE Heupink Tim H TH Macholdt Enrico E Peischl Stephan S Rasmussen Simon S Schiffels Stephan S Subramanian Sankar S Wright Joanne L JL Albrechtsen Anders A Barbieri Chiara C Dupanloup Isabelle I Eriksson Anders A Margaryan Ashot A Moltke Ida I Pugach Irina I Korneliussen Thorfinn S TS Levkivskyi Ivan P IP Moreno-Mayar J Víctor JV Ni Shengyu S Racimo Fernando F Sikora Martin M Xue Yali Y Aghakhanian Farhang A FA Brucato Nicolas N Brunak Søren S Campos Paula F PF Clark Warren W Ellingvåg Sturla S Fourmile Gudjugudju G Gerbault Pascale P Injie Darren D Koki George G Leavesley Matthew M Logan Betty B Lynch Aubrey A Matisoo-Smith Elizabeth A EA McAllister Peter J PJ Mentzer Alexander J AJ Metspalu Mait M Migliano Andrea B AB Murgha Les L Phipps Maude E ME Pomat William W Reynolds Doc D Ricaut Francois-Xavier FX Siba Peter P Thomas Mark G MG Wales Thomas T Wall Colleen Ma'run CM Oppenheimer Stephen J SJ Tyler-Smith Chris C Durbin Richard R Dortch Joe J Manica Andrea A Schierup Mikkel H MH Foley Robert A RA Lahr Marta Mirazón MM Bowern Claire C Wall Jeffrey D JD Mailund Thomas T Stoneking Mark M Nielsen Rasmus R Sandhu Manjinder S MS Excoffier Laurent L Lambert David M DM Willerslev Eske E

Nature 20160921 7624

The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australian ...[more]

PMID: 27654914

Publication: 1/2

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Project description:We applied the evaluation framework developed by the EU COST Action "Network of Evaluation of One Health" (NEOH) to assess the operations, supporting infrastructures and outcomes of a research consortium "University of Copenhagen Research Centre for Control of Antibiotic Resistance" (UC-CARE). This 4-year research project was a One Health (OH) initiative with participants from 14 departments over four faculties as well as stakeholders from industry and health authorities aiming to produce new knowledge to reduce the development of antimicrobial resistance (AMR). This was a case study focusing on assessing beneficial and counter-productive characteristics that could affect the OH outcomes. The study was also used to provide feedback to NEOH about the evaluation framework. The framework and evaluation tools are described in the introduction paper of this special journal issue. Data for the evaluation were extracted from the funding research proposal, the mid-term UC-CARE project evaluation report and supplemented with opinions elicited from project participants and stakeholders. Here, we describe the underlying system, theory of change behind the initiative and adapted questions from the NEOH tools that we used for semi-open interviews with consortium members throughout the evaluation process. An online survey was used to obtain information from stakeholders. The NEOH evaluation tools were then used for the qualitative and quantitative evaluation of the OH characteristics of UC-CARE. Senior UC-CARE researchers were interested and willing to be interviewed. Young scientists were more difficult to engage in interviews, and only 25% of stakeholders answered the online survey. Interviewees mentioned that the main benefit of UC-CARE was an increased awareness and general understanding of AMR issues. All interviewees stated that the adopted OH approach was relevant given the complexity of AMR. However, some questioned the applicability, and identified potentially counter-productive issues mainly related to the information sharing, collaboration and working methods across the consortium. A more integrated project organization, more stakeholder involvement and time for the project, flexibility in planning and a dedicated OH coordinator were suggested to allow for more knowledge exchange, potentially leading to a higher societal impact.

Project description:PurposeMigraine has consistently been connected with rosacea. Commonalities in epidemiology, trigger factors and associated neuropeptides support shared aetiology and pathophysiological pathways, though underlying mechanisms remain unclear. We established two cohorts of patients diagnosed with either migraine and/or rosacea. All patients were phenotyped in regard to migraine and rosacea. In this article, we describe the baseline parameters of the cohorts. In the future, we expect that these cohorts will help uncover potential disease overlaps and allow for prolonged follow-up through national Danish health registers.ParticipantsCOpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO) are prospective cohorts based in the Capital region of Denmark. Participants for COROCO were recruited primarily through two tertiary dermatology clinics in Copenhagen, Denmark and patients for COMICO were recruited through a tertiary neurology clinic in Copenhagen, Denmark.Findings to dateCOROCO: 67.7% women (median age 51 years (interquartile range (IQR) 43.0-61.0)). Family history of migraine: 44.3%. Family history of rosacea: 45%. There were 13% who currently smoked, and 36.6% were former smokers. Regular intake of alcohol was present in 79.3% (median 4 items/week (IQR 1.0-9.0)). Median body mass index (BMI): 25.7 (IQR 23.1-29.0). Median Dermatology Life Quality Index (DLQI): 2 (IQR 1-5).Comico88.5% women (median age 41 years (IQR 29.5-51.0)). Family history of migraine: 73.4%. Family history of rosacea: 18.4%. There were 17.1% who currently smoked, and 26.0% former smokers. Regular intake of alcohol was present in 62.2% (median intake: 2 item/week (IQR 1.0-3.0)). Median BMI was 24.6 (IQR 21.5-28.2). Median DLQI was 1 (IQR 0-2).Future plansCOROCO and COMICO serve as strong data sources that will be used for future studies on rosacea and migraine with focus on risk factors, occurrence, treatment, natural history, complications, comorbidities and prognosis.Trial registration numberClinicalTrials.gov Registry (NCT03872050).

Dataset Information

University of Copenhagen

Publications

A genomic history of Aboriginal Australia.

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