Helmholtz Zentrum Muenchen
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000793 | EGA |
REPOSITORIES: EGA
Publications
The genetic architecture of type 2 diabetes.
Fuchsberger Christian C Flannick Jason J Teslovich Tanya M TM Mahajan Anubha A Agarwala Vineeta V Gaulton Kyle J KJ Ma Clement C Fontanillas Pierre P Moutsianas Loukas L McCarthy Davis J DJ Rivas Manuel A MA Perry John R B JRB Sim Xueling X Blackwell Thomas W TW Robertson Neil R NR Rayner N William NW Cingolani Pablo P Locke Adam E AE Tajes Juan Fernandez JF Highland Heather M HM Dupuis Josee J Chines Peter S PS Lindgren Cecilia M CM Hartl Christopher C Jackson Anne U AU Chen Han H Huyghe Jeroen R JR van de Bunt Martijn M Pearson Richard D RD Kumar Ashish A Müller-Nurasyid Martina M Grarup Niels N Stringham Heather M HM Gamazon Eric R ER Lee Jaehoon J Chen Yuhui Y Scott Robert A RA Below Jennifer E JE Chen Peng P Huang Jinyan J Go Min Jin MJ Stitzel Michael L ML Pasko Dorota D Parker Stephen C J SCJ Varga Tibor V TV Green Todd T Beer Nicola L NL Day-Williams Aaron G AG Ferreira Teresa T Fingerlin Tasha T Horikoshi Momoko M Hu Cheng C Huh Iksoo I Ikram Mohammad Kamran MK Kim Bong-Jo BJ Kim Yongkang Y Kim Young Jin YJ Kwon Min-Seok MS Lee Juyoung J Lee Selyeong S Lin Keng-Han KH Maxwell Taylor J TJ Nagai Yoshihiko Y Wang Xu X Welch Ryan P RP Yoon Joon J Zhang Weihua W Barzilai Nir N Voight Benjamin F BF Han Bok-Ghee BG Jenkinson Christopher P CP Kuulasmaa Teemu T Kuusisto Johanna J Manning Alisa A Ng Maggie C Y MCY Palmer Nicholette D ND Balkau Beverley B Stančáková Alena A Abboud Hanna E HE Boeing Heiner H Giedraitis Vilmantas V Prabhakaran Dorairaj D Gottesman Omri O Scott James J Carey Jason J Kwan Phoenix P Grant George G Smith Joshua D JD Neale Benjamin M BM Purcell Shaun S Butterworth Adam S AS Howson Joanna M M JMM Lee Heung Man HM Lu Yingchang Y Kwak Soo-Heon SH Zhao Wei W Danesh John J Lam Vincent K L VKL Park Kyong Soo KS Saleheen Danish D So Wing Yee WY Tam Claudia H T CHT Afzal Uzma U Aguilar David D Arya Rector R Aung Tin T Chan Edmund E Navarro Carmen C Cheng Ching-Yu CY Palli Domenico D Correa Adolfo A Curran Joanne E JE Rybin Denis D Farook Vidya S VS Fowler Sharon P SP Freedman Barry I BI Griswold Michael M Hale Daniel Esten DE Hicks Pamela J PJ Khor Chiea-Chuen CC Kumar Satish S Lehne Benjamin B Thuillier Dorothée D Lim Wei Yen WY Liu Jianjun J van der Schouw Yvonne T YT Loh Marie M Musani Solomon K SK Puppala Sobha S Scott William R WR Yengo Loïc L Tan Sian-Tsung ST Taylor Herman A HA Thameem Farook F Wilson Gregory G Wong Tien Yin TY Njølstad Pål Rasmus PR Levy Jonathan C JC Mangino Massimo M Bonnycastle Lori L LL Schwarzmayr Thomas T Fadista João J Surdulescu Gabriela L GL Herder Christian C Groves Christopher J CJ Wieland Thomas T Bork-Jensen Jette J Brandslund Ivan I Christensen Cramer C Koistinen Heikki A HA Doney Alex S F ASF Kinnunen Leena L Esko Tõnu T Farmer Andrew J AJ Hakaste Liisa L Hodgkiss Dylan D Kravic Jasmina J Lyssenko Valeriya V Hollensted Mette M Jørgensen Marit E ME Jørgensen Torben T Ladenvall Claes C Justesen Johanne Marie JM Käräjämäki Annemari A Kriebel Jennifer J Rathmann Wolfgang W Lannfelt Lars L Lauritzen Torsten T Narisu Narisu N Linneberg Allan A Melander Olle O Milani Lili L Neville Matt M Orho-Melander Marju M Qi Lu L Qi Qibin Q Roden Michael M Rolandsson Olov O Swift Amy A Rosengren Anders H AH Stirrups Kathleen K Wood Andrew R AR Mihailov Evelin E Blancher Christine C Carneiro Mauricio O MO Maguire Jared J Poplin Ryan R Shakir Khalid K Fennell Timothy T DePristo Mark M de Angelis Martin Hrabé MH Deloukas Panos P Gjesing Anette P AP Jun Goo G Nilsson Peter P Murphy Jacquelyn J Onofrio Robert R Thorand Barbara B Hansen Torben T Meisinger Christa C Hu Frank B FB Isomaa Bo B Karpe Fredrik F Liang Liming L Peters Annette A Huth Cornelia C O'Rahilly Stephen P SP Palmer Colin N A CNA Pedersen Oluf O Rauramaa Rainer R Tuomilehto Jaakko J Salomaa Veikko V Watanabe Richard M RM Syvänen Ann-Christine AC Bergman Richard N RN Bharadwaj Dwaipayan D Bottinger Erwin P EP Cho Yoon Shin YS Chandak Giriraj R GR Chan Juliana C N JCN Chia Kee Seng KS Daly Mark J MJ Ebrahim Shah B SB Langenberg Claudia C Elliott Paul P Jablonski Kathleen A KA Lehman Donna M DM Jia Weiping W Ma Ronald C W RCW Pollin Toni I TI Sandhu Manjinder M Tandon Nikhil N Froguel Philippe P Barroso Inês I Teo Yik Ying YY Zeggini Eleftheria E Loos Ruth J F RJF Small Kerrin S KS Ried Janina S JS DeFronzo Ralph A RA Grallert Harald H Glaser Benjamin B Metspalu Andres A Wareham Nicholas J NJ Walker Mark M Banks Eric E Gieger Christian C Ingelsson Erik E Im Hae Kyung HK Illig Thomas T Franks Paul W PW Buck Gemma G Trakalo Joseph J Buck David D Prokopenko Inga I Mägi Reedik R Lind Lars L Farjoun Yossi Y Owen Katharine R KR Gloyn Anna L AL Strauch Konstantin K Tuomi Tiinamaija T Kooner Jaspal Singh JS Lee Jong-Young JY Park Taesung T Donnelly Peter P Morris Andrew D AD Hattersley Andrew T AT Bowden Donald W DW Collins Francis S FS Atzmon Gil G Chambers John C JC Spector Timothy D TD Laakso Markku M Strom Tim M TM Bell Graeme I GI Blangero John J Duggirala Ravindranath R Tai E Shyong ES McVean Gilean G Hanis Craig L CL Wilson James G JG Seielstad Mark M Frayling Timothy M TM Meigs James B JB Cox Nancy J NJ Sladek Rob R Lander Eric S ES Gabriel Stacey S Burtt Noël P NP Mohlke Karen L KL Meitinger Thomas T Groop Leif L Abecasis Goncalo G Florez Jose C JC Scott Laura J LJ Morris Andrew P AP Kang Hyun Min HM Boehnke Michael M Altshuler David D McCarthy Mark I MI
Nature 20160711 7614
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed ...[more]
