Dataset Information
Institute for Genetics of Heart Diseases (IfGH), Münster, Germany
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000932 | EGA |
REPOSITORIES: EGA
Publications
A Mutation in the G-Protein Gene <i>GNB2</i> Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.
Circulation research 20170220 10
<h4>Rationale</h4>Familial sinus node and atrioventricular conduction dysfunction is a rare disorder that leads to paroxysmal dizziness, fatigue, and syncope because of a temporarily or permanently reduced heart rate. To date, only a few genes for familial sinus and atrioventricular conduction dysfunction are known, and the majority of cases remain pathogenically unresolved.<h4>Objective</h4>We aim to identify the disease gene in a large 3-generation family (n=25) with autosomal dominant sinus n ...[more]
