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Omics score: 1000

Institute for Genetics of Heart Diseases (IfGH), MÃ¼nster, Germany

ABSTRACT: Organisation EGAO00000000932

PROVIDER: EGAO00000000932 | EGA |

REPOSITORIES: EGA

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A Mutation in the G-Protein Gene <i>GNB2</i> Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

Stallmeyer Birgit B Kuß Johanna J Kotthoff Stefan S Zumhagen Sven S Vowinkel Kirsty K Rinné Susanne S Matschke Lina A LA Friedrich Corinna C Schulze-Bahr Ellen E Rust Stephan S Seebohm Guiscard G Decher Niels N Schulze-Bahr Eric E

Circulation research 20170220 10

<h4>Rationale</h4>Familial sinus node and atrioventricular conduction dysfunction is a rare disorder that leads to paroxysmal dizziness, fatigue, and syncope because of a temporarily or permanently reduced heart rate. To date, only a few genes for familial sinus and atrioventricular conduction dysfunction are known, and the majority of cases remain pathogenically unresolved.<h4>Objective</h4>We aim to identify the disease gene in a large 3-generation family (n=25) with autosomal dominant sinus n ...[more]

PMID: 28219978

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