Dataset Information

Department of Pediatric Hemato-Oncology and Immunology, Medical Faculty, Heinrich-Heine-University, Dusseldorf 40225, Germany

ABSTRACT: Organisation EGAO00000000958

PROVIDER: EGAO00000000958 | EGA |

REPOSITORIES: EGA

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Publications

Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.

Schwartzman Omer O Savino Angela Maria AM Gombert Michael M Palmi Chiara C Cario Gunnar G Schrappe Martin M Eckert Cornelia C von Stackelberg Arend A Huang Jin-Yan JY Hameiri-Grossman Michal M Avigad Smadar S Te Kronnie Geertruy G Te Kronnie Geertruy G Geron Ifat I Birger Yehudit Y Rein Avigail A Zarfati Giulia G Fischer Ute U Mukamel Zohar Z Stanulla Martin M Biondi Andrea A Cazzaniga Giovanni G Vetere Amedeo A Wagner Bridget K BK Chen Zhu Z Chen Sai-Juan SJ Tanay Amos A Borkhardt Arndt A Izraeli Shai S

Proceedings of the National Academy of Sciences of the United States of America 20170501 20

Children with Down syndrome (DS) are prone to development of high-risk B-cell precursor ALL (DS-ALL), which differs genetically from most sporadic pediatric ALLs. Increased expression of cytokine receptor-like factor 2 (CRLF2), the receptor to thymic stromal lymphopoietin (TSLP), characterizes about half of DS-ALLs and also a subgroup of sporadic "Philadelphia-like" ALLs. To understand the pathogenesis of relapsed DS-ALL, we performed integrative genomic analysis of 25 matched diagnosis-remissio ...[more]

PMID: 28461505

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Project description:By means of the revision of the Medical Licensure Act for Physicians (ÄAppO) in 2009, undergraduate palliative care education (UPCE) was incorporated as a mandatory cross sectional examination subject (QB13) in medical education in Germany. Its implementation still constitutes a major challenge for German medical faculties. There is a discrepancy between limited university resources and limited patient availabilities and high numbers of medical students. Apart from teaching theoretical knowledge and skills, palliative care education is faced with the particular challenge of imparting a professional and adequate attitude towards incurably ill and dying patients and their relatives.Against this background, an evidence-based longitudinal UPCE curriculum was systematically developed following Kern's Cycle [1] and partly implemented and evaluated by the students participating in the pilot project. Innovative teaching methods (virtual standardised/simulated patient contacts, e-learning courses, interdisciplinary and interprofessional collaborative teaching, and group sessions for reflective self-development) aim at teaching palliative care-related core competencies within the clinical context and on an interdisciplinary and interprofessional basis.After almost five years of development and evaluation, the UPCE curriculum comprises 60 teaching units and is being fully implemented and taught for the first time in the winter semester 2014/15. The previous pilot phases were successfully concluded. To date, the pilot phases (n=26), the subproject "E-learning in palliative care" (n=518) and the blended-learning elective course "Communication with dying patients" (n=12) have been successfully evaluated.All conducted development steps and all developed programmes are available for other palliative care educators (Open Access). The integrated teaching formats and methods (video, e-learning module, interprofessional education, group sessions for reflexive self-development) and their evaluations are intended to make a contribution to an evidence-based development of palliative care curricula in Germany.

Dataset Information

Department of Pediatric Hemato-Oncology and Immunology, Medical Faculty, Heinrich-Heine-University, Dusseldorf 40225, Germany

Publications

Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.

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