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Omics score: 1000

The Scripps Translational Science Institute

ABSTRACT: Organisation EGAO00000000995

PROVIDER: EGAO00000000995 | EGA |

REPOSITORIES: EGA

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Publications

Whole-Genome Sequencing of a Healthy Aging Cohort.

Erikson Galina A GA Bodian Dale L DL Rueda Manuel M Molparia Bhuvan B Scott Erick R ER Scott-Van Zeeland Ashley A AA Topol Sarah E SE Wineinger Nathan E NE Niederhuber John E JE Topol Eric J EJ Torkamani Ali A

Cell 20160421 4

Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease. Therefore, we pursued genome sequencing of a related phenotype-healthy aging-to understand the genetics of disease-free aging without medical intervention. In contrast with studies of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known longevity variants, but is associated with reduced genetic susceptibility to Alzheimer and coronary ...[more]

PMID: 27114037

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