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Omics score: 1000

LMU MÃ¼nchen

ABSTRACT: Organisation EGAO00000001034

PROVIDER: EGAO00000001034 | EGA |

REPOSITORIES: EGA

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Publications

Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.

Oak Prajakta P Pritzke Tina T Thiel Isabella I Koschlig Markus M Mous Daphne S DS Windhorst Anita A Jain Noopur N Eickelberg Oliver O Foerster Kai K Schulze Andreas A Goepel Wolfgang W Reicherzer Tobias T Ehrhardt Harald H Rottier Robbert J RJ Ahnert Peter P Gortner Ludwig L Desai Tushar J TJ Hilgendorff Anne A

EMBO molecular medicine 20171101 11

Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O2). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O2 In the context of MV-O2, attenuated PDGF ...[more]

PMID: 28923828

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The ProMotion LMU dataset, prostate intra-fraction motion recorded by transperineal ultrasound.

Project description:Intra-fraction motion of the prostate was recorded during 721 fractions of image guided radiotherapy (IGRT) in 28 patients, 14 of which were treated by intensity modulated radiation therapy (IMRT), and 14 of which were treated by volumetric arc therapy (VMAT). The prostate was imaged by three-dimensional and time-resolved transperineal ultrasound (4D-US) of type Clarity by Elekta, Stockholm, Sweden. The prostate volume was registered and the prostate position (center of volume) was recorded at a frequency of 1.6 samples per second. This raw data set contains a total of 380.199 prostate and patient couch positions over a time span of 53?hours, 47?minutes and 29?seconds of life radiotherapy as exported by the instrument software. This data set has been used for the validation of models of prostate intra-fraction motion and for the estimation of the dosimetric impact of actual intra-fraction motion on treatment quality and side effects. We hope that this data set may be reused by other groups for similar purposes.

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Institut National pour la SantÃ© et la Recherche MÃ©dicale (INSERM), France

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RNA-Seq of polyA mRNA from rare types of cultured or uncultured primary cells of different haemopoetic lineages from healthy individuals in the BLUEPRINT epigenome project (Expression Atlas tissue view)

Project description:This experiment contains a subset of data from the BLUEPRINT Epigenome project ( http://www.blueprint-epigenome.eu ), which aims at producing a reference haemopoetic epigenomes for the research community. 29 samples of primary cells or cultured primary cells of different haemopoeitc lineages from cord blood are included in this experiment. This ArrayExpress record contains only meta-data. Raw data files have been archived at the European Genome-Phenome Archive (EGA, www.ebi.ac.uk/ega) by the consortium, with restricted access to protect sample donors' identity. The relevant accessions of EGA data sets is EGAD00001001165. Details on how to apply for data access via the BLUEPRINT data access committee are on the EGA data set pages. The mapping of samples to these EGA accessions can be found in the 'Sample Data Relationship Format' file of this ArrayExpress record. Information on individual samples and sequencing libraries can also be found on the BLUEPRINT data coordination centre (DCC) website: http://dcc.blueprint-epigenome.eu

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RNA-Seq of polyA mRNA from plasma cells of tonsil from healthy individuals in the BLUEPRINT epigenome project

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