Dataset Information
Medizinische Universität Wien
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000001035 | EGA |
REPOSITORIES: EGA
Publications
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.
EMBO molecular medicine 20171101 11
Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O<sub>2</sub>). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O<sub>2</sub> In the context of MV-O<sub>2</sub>, attenuated PDGF ...[more]