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Dataset Information

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Karolinska Institute

ABSTRACT: Organisation EGAO00000001154

PROVIDER: EGAO00000001154 | EGA |

REPOSITORIES: EGA

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Publications

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Xu Cheng-Jian CJ   Söderhäll Cilla C   Bustamante Mariona M   Baïz Nour N   Gruzieva Olena O   Gehring Ulrike U   Mason Dan D   Chatzi Leda L   Basterrechea Mikel M   Llop Sabrina S   Torrent Maties M   Forastiere Francesco F   Fantini Maria Pia MP   Carlsen Karin C Lødrup KCL   Haahtela Tari T   Morin Andréanne A   Kerkhof Marjan M   Merid Simon Kebede SK   van Rijkom Bianca B   Jankipersadsing Soesma A SA   Bonder Marc Jan MJ   Ballereau Stephane S   Vermeulen Cornelis J CJ   Aguirre-Gamboa Raul R   de Jongste Johan C JC   Smit Henriette A HA   Kumar Ashish A   Pershagen Göran G   Guerra Stefano S   Garcia-Aymerich Judith J   Greco Dario D   Reinius Lovisa L   McEachan Rosemary R C RRC   Azad Raf R   Hovland Vegard V   Mowinckel Petter P   Alenius Harri H   Fyhrquist Nanna N   Lemonnier Nathanaël N   Pellet Johann J   Auffray Charles C   van der Vlies Pieter P   van Diemen Cleo C CC   Li Yang Y   Wijmenga Cisca C   Netea Mihai G MG   Moffatt Miriam F MF   Cookson William O C M WOCM   Anto Josep M JM   Bousquet Jean J   Laatikainen Tiina T   Laprise Catherine C   Carlsen Kai-Håkon KH   Gori Davide D   Porta Daniela D   Iñiguez Carmen C   Bilbao Jose Ramon JR   Kogevinas Manolis M   Wright John J   Brunekreef Bert B   Kere Juha J   Nawijn Martijn C MC   Annesi-Maesano Isabella I   Sunyer Jordi J   Melén Erik E   Koppelman Gerard H GH  

The Lancet. Respiratory medicine 20180226 5

<h4>Background</h4>DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma.<h4>Methods</h4>We did a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project. We examined epigenome-wide methylation using Illumina Infinium Human Methylation450 BeadChips (450K) in whole blo  ...[more]

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