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Omics score: 1000

UMC

ABSTRACT: Organisation EGAO00000001346

PROVIDER: EGAO00000001346 | EGA |

REPOSITORIES: EGA

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Publications

Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo.

Chen Hung-Jen HJ Li Yim Andrew Y F AYF Griffith Guillermo R GR de Jonge Wouter J WJ Mannens Marcel M A M MMAM Ferrero Enrico E Henneman Peter P de Winther Menno P J MPJ

Frontiers in immunology 20191211

Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used in vitro macrophage models to perform a meta-analysis. Specifically, we obtained gene expression data from unstimulated macrophages (M0) and macrophages stimulated with lipopolysaccharid ...[more]

PMID: 31921150

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