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WTCCC case-control study for Coronary Artery Disease, Hypertension, T2D - combined cases

ABSTRACT: WTCCC genome-wide case-control association study using the cardiovascular disease CAD, HT and T2D as combined case collection and the 1958 British Birth Cohort and the UK National Blood Service collections as controls.

PROVIDER: EGAS00000000005 | EGA |

REPOSITORIES: EGA

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Nature 20070601 7145

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5 ...[more]

PMID: 17554300

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