Genomics

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WTCCC case-control study for T1D and RA - combined cases

ABSTRACT: WTCCC genome-wide case-control association study using two disease collections together with the 1958 British Birth Cohort and the UK National Blood Service collections as controls.

PROVIDER: EGAS00000000013 | EGA |

REPOSITORIES: EGA

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Publications

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Nature 20070601 7145

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5  ...[more]

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