Genomics

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Genome wide association scan in Parkinson's disease

ABSTRACT: Genome-wide association scan was performed in 1,705 cases of parkinson's genotyped on the Illumina Human 660W SNP array, and 5,175 controls genotyped on the Illumina1.2M-Duo. Analysis was carried out on the overlaps set of SNPs.

PROVIDER: EGAS00000000034 | EGA |

REPOSITORIES: EGA

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Publications

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

Spencer Chris C A CC   Plagnol Vincent V   Strange Amy A   Gardner Michelle M   Paisan-Ruiz Coro C   Band Gavin G   Barker Roger A RA   Bellenguez Celine C   Bhatia Kailash K   Blackburn Hannah H   Blackwell Jennie M JM   Bramon Elvira E   Brown Martin A MA   Brown Matthew A MA   Burn David D   Casas Juan-Pablo JP   Chinnery Patrick F PF   Clarke Carl E CE   Corvin Aiden A   Craddock Nicholas N   Deloukas Panos P   Edkins Sarah S   Evans Jonathan J   Freeman Colin C   Gray Emma E   Hardy John J   Hudson Gavin G   Hunt Sarah S   Jankowski Janusz J   Langford Cordelia C   Lees Andrew J AJ   Markus Hugh S HS   Mathew Christopher G CG   McCarthy Mark I MI   Morrison Karen E KE   Palmer Colin N A CN   Pearson Justin P JP   Peltonen Leena L   Pirinen Matti M   Plomin Robert R   Potter Simon S   Rautanen Anna A   Sawcer Stephen J SJ   Su Zhan Z   Trembath Richard C RC   Viswanathan Ananth C AC   Williams Nigel W NW   Morris Huw R HR   Donnelly Peter P   Wood Nicholas W NW  

Human molecular genetics 20101102 2

We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 French PD cases and 1984 controls for the 27 regions showing the strongest evidence of association (P< 10(-4)). We replicated published associations in the 4q22/SNCA and 17q21/MAPT chromosome regions (P< 10(-10)) and found evidence for an additional independent association in  ...[more]

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