Dataset Information

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

ABSTRACT: Based on the prior knowledge of involvement of the human leukocyte antigen locus in Han Chinese patients with carbamazepine-induced Stevens-Johnson syndrome, we imputed the HLA types for each case and control subject from the array of SNPs in the Human610-Quad GWAS platform (NCBI Build 36.1). We then performed a genome-wide association test which included the imputed HLA alleles as markers.

PROVIDER: EGAS00000000036 | EGA |

REPOSITORIES: EGA

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HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

McCormack Mark M Alfirevic Ana A Bourgeois Stephane S Farrell John J JJ Kasperavičiūtė Dalia D Carrington Mary M Sills Graeme J GJ Marson Tony T Jia Xiaoming X de Bakker Paul I W PI Chinthapalli Krishna K Molokhia Mariam M Johnson Michael R MR O'Connor Gerard D GD Chaila Elijah E Alhusaini Saud S Shianna Kevin V KV Radtke Rodney A RA Heinzen Erin L EL Walley Nicole N Pandolfo Massimo M Pichler Werner W Park B Kevin BK Depondt Chantal C Sisodiya Sanjay M SM Goldstein David B DB Deloukas Panos P Delanty Norman N Cavalleri Gianpiero L GL Pirmohamed Munir M

The New England journal of medicine 20110301 12

<h4>Background</h4>Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.<h4>Methods</h4>We performed a genomewide association study of samples obtained from 22 subjects with carbamaze ...[more]

PMID: 21428769

Dataset Information

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

Publications

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

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