Dataset Information

Carbamazepine-induced hypersensitivity reactions in Europeans

ABSTRACT: An antiepileptic drug carbamazepine is well tolerated by the majority of patients, but can cause severe and potentialy fatal hypersensitivity reactions in a small number of individuals. The aim of this study was to identify genetic predictors of hypersensitivity reactions to carbamazepine. We undertook a genome-wide association study (GWAS) in 22 patients of European ancestry with carbamazepine-induced hypersensitivity syndrome (HSS) and compared our data with genotypes from a healthy population within the WTCCC. We performed imputation of classical HLA alleles according to a recently described method (Science. 2010 Dec 10;330(6010):1551-7. Epub 2010 Nov 4). GWAS statistical analysis was performed using logistic regression with an additive model of inheritance.

PROVIDER: EGAS00000000037 | EGA |

REPOSITORIES: EGA

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HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

McCormack Mark M Alfirevic Ana A Bourgeois Stephane S Farrell John J JJ Kasperavičiūtė Dalia D Carrington Mary M Sills Graeme J GJ Marson Tony T Jia Xiaoming X de Bakker Paul I W PI Chinthapalli Krishna K Molokhia Mariam M Johnson Michael R MR O'Connor Gerard D GD Chaila Elijah E Alhusaini Saud S Shianna Kevin V KV Radtke Rodney A RA Heinzen Erin L EL Walley Nicole N Pandolfo Massimo M Pichler Werner W Park B Kevin BK Depondt Chantal C Sisodiya Sanjay M SM Goldstein David B DB Deloukas Panos P Delanty Norman N Cavalleri Gianpiero L GL Pirmohamed Munir M

The New England journal of medicine 20110301 12

<h4>Background</h4>Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.<h4>Methods</h4>We performed a genomewide association study of samples obtained from 22 subjects with carbamaze ...[more]

PMID: 21428769

Dataset Information

Carbamazepine-induced hypersensitivity reactions in Europeans

Publications

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

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