Ontology highlight
ABSTRACT:
PROVIDER: EGAS00000000052 | EGA |
REPOSITORIES: EGA
Nature 20091216 7278
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here we have sequenced the genomes of a malignant melanoma and a lymphoblastoid cell line from the same person, providing the first comprehensive catalogue of somatic mutations from an individual cancer. The catalogue provides remarkable insights into the forces that have shaped this ...[more]