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A genome-wide meta analysis on stroke and ischemic stroke within four populations

ABSTRACT: In this analysis a genome-wide meta-analysis was performed on all stroke and ischemic stroke.

PROVIDER: EGAS00000000060 | EGA |

REPOSITORIES: EGA

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Genomewide association studies of stroke.

Ikram M Arfan MA Seshadri Sudha S Bis Joshua C JC Fornage Myriam M DeStefano Anita L AL Aulchenko Yurii S YS Debette Stephanie S Lumley Thomas T Folsom Aaron R AR van den Herik Evita G EG Bos Michiel J MJ Beiser Alexa A Cushman Mary M Launer Lenore J LJ Shahar Eyal E Struchalin Maksim M Du Yangchun Y Glazer Nicole L NL Rosamond Wayne D WD Rivadeneira Fernando F Kelly-Hayes Margaret M Lopez Oscar L OL Coresh Josef J Hofman Albert A DeCarli Charles C Heckbert Susan R SR Koudstaal Peter J PJ Yang Qiong Q Smith Nicholas L NL Kase Carlos S CS Rice Kenneth K Haritunians Talin T Roks Gerwin G de Kort Paul L M PL Taylor Kent D KD de Lau Lonneke M LM Oostra Ben A BA Uitterlinden Andre G AG Rotter Jerome I JI Boerwinkle Eric E Psaty Bruce M BM Mosley Thomas H TH van Duijn Cornelia M CM Breteler Monique M B MM Longstreth W T WT Wolf Philip A PA

The New England journal of medicine 20090415 17

<h4>Background</h4>The genes underlying the risk of stroke in the general population remain undetermined.<h4>Methods</h4>We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [+/-SD] age, 63+/-8 years) in whom 1544 incident strokes (1164 ischemic strokes) developed over an average follow-up of 11 years. We tested the markers most strong ...[more]

PMID: 19369658

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