Genomics

Dataset Information

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Pancreatic Cancer Sequencing Initiative

ABSTRACT: Pancreatic Cancer Sequencing Initiative for the International Cancer Genome Consortium at the Ontario Institute for Cancer Research.

PROVIDER: EGAS00001000343 | EGA |

REPOSITORIES: EGA

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Publications

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Biankin Andrew V AV   Waddell Nicola N   Kassahn Karin S KS   Gingras Marie-Claude MC   Muthuswamy Lakshmi B LB   Johns Amber L AL   Miller David K DK   Wilson Peter J PJ   Patch Ann-Marie AM   Wu Jianmin J   Chang David K DK   Cowley Mark J MJ   Gardiner Brooke B BB   Song Sarah S   Harliwong Ivon I   Idrisoglu Senel S   Nourse Craig C   Nourbakhsh Ehsan E   Manning Suzanne S   Wani Shivangi S   Gongora Milena M   Pajic Marina M   Scarlett Christopher J CJ   Gill Anthony J AJ   Pinho Andreia V AV   Rooman Ilse I   Anderson Matthew M   Holmes Oliver O   Leonard Conrad C   Taylor Darrin D   Wood Scott S   Xu Qinying Q   Nones Katia K   Fink J Lynn JL   Christ Angelika A   Bruxner Tim T   Cloonan Nicole N   Kolle Gabriel G   Newell Felicity F   Pinese Mark M   Mead R Scott RS   Humphris Jeremy L JL   Kaplan Warren W   Jones Marc D MD   Colvin Emily K EK   Nagrial Adnan M AM   Humphrey Emily S ES   Chou Angela A   Chin Venessa T VT   Chantrill Lorraine A LA   Mawson Amanda A   Samra Jaswinder S JS   Kench James G JG   Lovell Jessica A JA   Daly Roger J RJ   Merrett Neil D ND   Toon Christopher C   Epari Krishna K   Nguyen Nam Q NQ   Barbour Andrew A   Zeps Nikolajs N   Kakkar Nipun N   Zhao Fengmei F   Wu Yuan Qing YQ   Wang Min M   Muzny Donna M DM   Fisher William E WE   Brunicardi F Charles FC   Hodges Sally E SE   Reid Jeffrey G JG   Drummond Jennifer J   Chang Kyle K   Han Yi Y   Lewis Lora R LR   Dinh Huyen H   Buhay Christian J CJ   Beck Timothy T   Timms Lee L   Sam Michelle M   Begley Kimberly K   Brown Andrew A   Pai Deepa D   Panchal Ami A   Buchner Nicholas N   De Borja Richard R   Denroche Robert E RE   Yung Christina K CK   Serra Stefano S   Onetto Nicole N   Mukhopadhyay Debabrata D   Tsao Ming-Sound MS   Shaw Patricia A PA   Petersen Gloria M GM   Gallinger Steven S   Hruban Ralph H RH   Maitra Anirban A   Iacobuzio-Donahue Christine A CA   Schulick Richard D RD   Wolfgang Christopher L CL   Morgan Richard A RA   Lawlor Rita T RT   Capelli Paola P   Corbo Vincenzo V   Scardoni Maria M   Tortora Giampaolo G   Tempero Margaret A MA   Mann Karen M KM   Jenkins Nancy A NA   Perez-Mancera Pedro A PA   Adams David J DJ   Largaespada David A DA   Wessels Lodewyk F A LF   Rust Alistair G AG   Stein Lincoln D LD   Tuveson David A DA   Copeland Neal G NG   Musgrove Elizabeth A EA   Scarpa Aldo A   Eshleman James R JR   Hudson Thomas J TJ   Sutherland Robert L RL   Wheeler David A DA   Pearson John V JV   McPherson John D JD   Gibbs Richard A RA   Grimmond Sean M SM  

Nature 20121024 7424

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutation  ...[more]

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