Dataset Information

The landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes

ABSTRACT: To define the frequency and pattern of somatic mutations in epigenetic regulators in pediatric cancer, we sequenced 633 genes, encoding the majority of proteins involved in patterning the epigenome, in 1000 pediatric tumors spanning 21 different cancer subtypes. This analysis establishes an epigenetic landscape of pediatric cancer, which expands the knowledge for potential therapeutic targets and for developing personalized therapy.

PROVIDER: EGAS00001000449 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Publications

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

Jaffe Jacob D JD Wang Yan Y Chan Ho Man HM Zhang Jinghui J Huether Robert R Kryukov Gregory V GV Bhang Hyo-eun C HE Taylor Jordan E JE Hu Min M Englund Nathan P NP Yan Feng F Wang Zhaofu Z Robert McDonald E E Wei Lei L Ma Jing J Easton John J Yu Zhengtian Z deBeaumount Rosalie R Gibaja Veronica V Venkatesan Kavitha K Schlegel Robert R Sellers William R WR Keen Nicholas N Liu Jun J Caponigro Giordano G Barretina Jordi J Cooke Vesselina G VG Mullighan Charles C Carr Steven A SA Downing James R JR Garraway Levi A LA Stegmeier Frank F

Nature genetics 20130929 11

Epigenetic dysregulation is an emerging hallmark of cancers. We developed a high-information-content mass spectrometry approach to profile global histone modifications in human cancers. When applied to 115 lines from the Cancer Cell Line Encyclopedia, this approach identified distinct molecular chromatin signatures. One signature was characterized by increased histone 3 lysine 36 (H3K36) dimethylation, exhibited by several lines harboring translocations in NSD2, which encodes a methyltransferase ...[more]

PMID: 24076604

Dataset Information

The landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes

Publications

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

1000 Genomes Phase 3 aCGH samples
2015-07-01 | GSE70188 | GEO

1000 Genomes Phase 3 aCGH samples
2015-07-01 | E-GEOD-70188 | biostudies-arrayexpress

Epigenetic Landscape of Pediatric Ependymoma Recurrence
| PRJNA658524 | ENA

Mycoplasma contamination in the 1000 Genomes Project.
| S-EPMC4022254 | biostudies-literature

HLA diversity in the 1000 genomes dataset.
| S-EPMC4079705 | biostudies-literature

The landscape of somatic alterations in epigenetic genes across 21 pediatric cancers
2013-12-31 | E-GEOD-43209 | biostudies-arrayexpress

Lin28 sustains early renal progenitors and induces Wilms tumor
2014-06-01 | E-GEOD-56323 | biostudies-arrayexpress

RNA-seq from four balanced translocation carriers in 1000 Genomes Project
2017-07-01 | GSE94043 | GEO