Dataset Information

Illumina Human OmniExpress genotyping data from the Cretan Greek isolate collection HELIC MANOLIS

ABSTRACT: Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies. Here we have genotyped individuals from a Greek population isolate on the Illumina Human OmniExpress BeadChip array. The HELIC (Hellenic Isolated Cohorts) MANOLIS (Minoan Isolates) collection focuses on Anogia and surrounding Mylopotamos villages. Recruitment of this population-based sample was primarily carried out at the village medical centres. All individuals were older than 17 years and had to have at least one parent from the Mylopotamos area. www.helic.org **The data may not be used for population genetics analyses**

PROVIDER: EGAS00001000687 | EGA |

REPOSITORIES: EGA

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Publications

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.

Panoutsopoulou Kalliope K Hatzikotoulas Konstantinos K Xifara Dionysia Kiara DK Colonna Vincenza V Farmaki Aliki-Eleni AE Ritchie Graham R S GR Southam Lorraine L Gilly Arthur A Tachmazidou Ioanna I Fatumo Segun S Matchan Angela A Rayner Nigel W NW Ntalla Ioanna I Mezzavilla Massimo M Chen Yuan Y Kiagiadaki Chrysoula C Zengini Eleni E Mamakou Vasiliki V Athanasiadis Antonis A Giannakopoulou Margarita M Kariakli Vassiliki-Eirini VE Nsubuga Rebecca N RN Karabarinde Alex A Sandhu Manjinder M McVean Gil G Tyler-Smith Chris C Tsafantakis Emmanouil E Karaleftheri Maria M Xue Yali Y Dedoussis George G Zeggini Eleftheria E

Nature communications 20141106

Isolated populations are emerging as a powerful study design in the search for low-frequency and rare variant associations with complex phenotypes. Here we genotype 2,296 samples from two isolated Greek populations, the Pomak villages (HELIC-Pomak) in the North of Greece and the Mylopotamos villages (HELIC-MANOLIS) in Crete. We compare their genomic characteristics to the general Greek population and establish them as genetic isolates. In the MANOLIS cohort, we observe an enrichment of missense ...[more]

PMID: 25373335

Dataset Information

Illumina Human OmniExpress genotyping data from the Cretan Greek isolate collection HELIC MANOLIS

Publications

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.

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