Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001000729 | EGA |
REPOSITORIES: EGA
Viros Amaya A Sanchez-Laorden Berta B Pedersen Malin M Furney Simon J SJ Rae Joel J Hogan Kate K Ejiama Sarah S Girotti Maria Romina MR Cook Martin M Dhomen Nathalie N Marais Richard R
Nature 20140611 7510
Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear. The most common somatic mutation in melanoma is a V600E substitution in BRAF, which is an early event. To investigate how UVR accelerates oncogenic BRAF-driven melanomagenesis, we used a BRAF(V600E) mouse model. In mice expressing BRAF(V600E) in their melanocytes, a single dose of UVR that mimicked mild sunburn in humans induced clonal ex ...[more]