Project description:RNA sequencing of the chromatin associated RNA and nucleoplasm associated RNA of Naive CD4+ T cells to identify novel chromatin associated RNAs containing TEs. RNA sequencing of Naive CD4+ T cells or Activated Naive CD4+ T cells treated with Scr or LINE1 antisense oligonucleotides (ASO).
Project description:RNA sequencing of human neonatal Naive CD4+ T cells and adult Naive CD4+ T cells treated with Scr or LINE1 ASO to assess functional relevance of LINE1 absence in newborns.
Project description:H3K36me3 ChIP sequencing performed on circulating ex vivo isolated CD4+ Naive T cells under LINE1 RNA knock-down and control conditions