Whole genome DNA sequencing for two long-lived humans.
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001000877 | EGA |
REPOSITORIES: EGA
Publications
Mobster: accurate detection of mobile element insertions in next generation sequencing data.
Thung Djie Tjwan DT de Ligt Joep J Vissers Lisenka E M LE Steehouwer Marloes M Kroon Mark M de Vries Petra P Slagboom Eline P EP Ye Kai K Veltman Joris A JA Hehir-Kwa Jayne Y JY
Genome biology 20140101 10
Mobile elements are major drivers in changing genomic architecture and can cause disease. The detection of mobile elements is hindered due to the low mappability of their highly repetitive sequences. We have developed an algorithm, called Mobster, to detect non-reference mobile element insertions in next generation sequencing data from both whole genome and whole exome studies. Mobster uses discordant read pairs and clipped reads in combination with consensus sequences of known active mobile ele ...[more]
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