Genomics

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DNA methylation repeatability in the Lothian Birth Cohorts of 1921 and 1936.

ABSTRACT: The repeatability of longitudinal measures of whole blood DNA methylation (obtained using the Illumina 450k chip) was assessed in two cohorts of ageing. The Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936. Data were collected at ages 70, 73, and 76 (LBC1936) and 79, 87, 90 (LBC1921) with 478 participants having two or more measures of methylation.

PROVIDER: EGAS00001000910 | EGA |

REPOSITORIES: EGA

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<h4>Background</h4>The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.<h4>Methods</h4>DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed o  ...[more]

PMID: 25617346

Publication: 1/5

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