Genomics,Multiomics

Dataset Information

6

DNA methylation repeatability in the Lothian Birth Cohorts of 1921 and 1936.

ABSTRACT: The repeatability of longitudinal measures of whole blood DNA methylation (obtained using the Illumina 450k chip) was assessed in two cohorts of ageing. The Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936. Data were collected at ages 70, 73, and 76 (LBC1936) and 79, 87, 90 (LBC1921) with 478 participants having two or more measures of methylation.

PROVIDER: EGAS00001000910 | EGA |

REPOSITORIES: EGA

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<h4>Background</h4>DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age.<h4>Results</h4>Here we test whether differences between people's chronological ages and estimated ages, DNA methylation age, predict all-cause mortality in later life. The difference between DNA methylation age and chronological age (Δage) was calculated in fou  ...[more]

PMID: 25633388

Publication: 1/5

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