Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001001015 | EGA |
REPOSITORIES: EGA
Spans Lien L Van den Broeck Thomas T Smeets Elien E Prekovic Stefan S Thienpont Bernard B Lambrechts Diether D Karnes R Jeffrey RJ Erho Nicholas N Alshalalfa Mohammed M Davicioni Elai E Helsen Christine C Gevaert Thomas T Tosco Lorenzo L Haustermans Karin K Lerut Evelyne E Joniau Steven S Claessens Frank F
Oncotarget 20160401 17
The clinical heterogeneity of prostate cancer (PCa) makes it difficult to identify those patients that could benefit from more aggressive treatments. As a contribution to a better understanding of the genomic changes in the primary tumor that are associated with the development of high-risk disease, we performed exome sequencing and copy number determination of a clinically homogeneous cohort of 47 high-risk PCas. We confirmed recurrent mutations in SPOP, PTEN and TP53 among the 850 point mutati ...[more]