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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

ABSTRACT: Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

PROVIDER: EGAS00001001024 | EGA |

REPOSITORIES: EGA

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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.

Jiang Peiyong P Chan Carol W M CW Chan K C Allen KC Cheng Suk Hang SH Wong John J Wong Vincent Wai-Sun VW Wong Grace L H GL Chan Stephen L SL Mok Tony S K TS Chan Henry L Y HL Lai Paul B S PB Chiu Rossa W K RW Lo Y M Dennis YM

Proceedings of the National Academy of Sciences of the United States of America 20150202 11

The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for performing liquid biopsies for the assessment of solid tumors. Although its clinical potential has been increasingly recognized, many aspects of the biological characteristics of tumor-derived cell-free DNA remain unclear. With respect to the size profile of such plasma DNA molecules, a number of studies reported the finding of increased integrity of tumor-derived plasma DNA, whereas others found evidence to s ...[more]

PMID: 25646427

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