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BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins

ABSTRACT: BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins

PROVIDER: EGAS00001001598 | EGA |

REPOSITORIES: EGA

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Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.

Paul Dirk S DS Teschendorff Andrew E AE Dang Mary A N MA Lowe Robert R Hawa Mohammed I MI Ecker Simone S Beyan Huriya H Cunningham Stephanie S Fouts Alexandra R AR Ramelius Anita A Burden Frances F Farrow Samantha S Rowlston Sophia S Rehnstrom Karola K Frontini Mattia M Downes Kate K Busche Stephan S Cheung Warren A WA Ge Bing B Simon Marie-Michelle MM Bujold David D Kwan Tony T Bourque Guillaume G Datta Avik A Lowy Ernesto E Clarke Laura L Flicek Paul P Libertini Emanuele E Heath Simon S Gut Marta M Gut Ivo G IG Ouwehand Willem H WH Pastinen Tomi T Soranzo Nicole N Hofer Sabine E SE Karges Beate B Meissner Thomas T Boehm Bernhard O BO Cilio Corrado C Elding Larsson Helena H Lernmark Åke Å Steck Andrea K AK Rakyan Vardhman K VK Beck Stephan S Leslie R David RD

Nature communications 20161129

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide association study across 406,365 CpGs in 52 monozygotic twin pairs discordant for T1D in three immune effector cell types. We observe a substantial enrichment of differentially variable CpG positions (DVPs) in T1D twins when compared with their healthy co-twins and when compared w ...[more]

PMID: 27898055

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