Dataset Information

Evolutionary Genome Analysis of Transformation into Small Cell Carcinomas from Lung Adenocarcinomas

ABSTRACT: Anecdotal case have been reported lung adenocarcinoma could occasionally transform into small cell carcinoma. Most of the reported cases were EGFR-mutant lung adenocarcinomas that transform into small cell carcinoma during EGFR tyrosine kinase inhibitor treatment. However, some cases also indicate lung adenocarcinomas without EGFR mutation could also transform into small cell carcinomas. Here we investigate this transformation process by whole genome sequencing of transformed small cell carcinomas as well as serially acquired samples of lung adenocarcinoma into small cell carcinomas.

PROVIDER: EGAS00001001757 | EGA |

REPOSITORIES: EGA

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Publications

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas.

Lee June-Koo JK Lee Junehawk J Kim Sehui S Kim Soyeon S Youk Jeonghwan J Park Seongyeol S An Yohan Y Keam Bhumsuk B Kim Dong-Wan DW Heo Dae Seog DS Kim Young Tae YT Kim Jin-Soo JS Kim Se Hyun SH Lee Jong Seok JS Lee Se-Hoon SH Park Keunchil K Ku Ja-Lok JL Jeon Yoon Kyung YK Chung Doo Hyun DH Park Peter J PJ Kim Joon J Kim Tae Min TM Ju Young Seok YS

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20170512 26

Purpose Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the molecular pathogenesis is still unclear. Methods We investigated 21 patients with advanced EGFR-mutant LADCs that were transformed into EGFR TKI-resistant SCLCs. Among them, whole genome sequencing was applied for nine tumors acquired at ...[more]

PMID: 28498782

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Dataset Information

Evolutionary Genome Analysis of Transformation into Small Cell Carcinomas from Lung Adenocarcinomas

Publications

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas.

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