Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001002276 | EGA |
REPOSITORIES: EGA
Sierra Beatriz B Triska Petr P Soares Pedro P Garcia Gissel G Perez Ana B AB Aguirre Eglys E Oliveira Marisa M Cavadas Bruno B Regnault Béatrice B Alvarez Mayling M Ruiz Didye D Samuels David C DC Sakuntabhai Anavaj A Pereira Luisa L Guzman Maria G MG
PLoS pathogens 20170227 2
Ethnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective against the haemorrhagic phenotype. Global ancestry analysis based on high-throughput genotyping in admixed populations can be used to test this hypothesis, while admixture mapping can map candidate protective genes. A Cuban dengue fever cohort was genotyped us ...[more]