Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH
Ontology highlight
ABSTRACT: Initially IDH1 mutant gliomas are shown to have IDH1 is deletions or amplifications at recurrence yielding a higher-grade tumor with a reprogrammed epigenome. We also report systematic selection for cells with IDH1 CNA in vitro and in vivo.
PROVIDER: EGAS00001002618 | EGA |
REPOSITORIES: EGA
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