Age-related remodeling of apparently normal esophageal epithelia by common cancer drivers

ABSTRACT: Driver mutated clones multi-focally emerged from early adulthood and over years, increase their number and size, ultimately remodeling the entire esophageal epithelia in extreme elderly. Our results suggest that clonal expansion in esophageal epithelia is an inevitable consequence of normal aging, differentially impacting the development of cancer depending on mutation type and exposure to drinking and smoking.

PROVIDER: EGAS00001003008 | EGA |

REPOSITORIES: EGA