Genomics

Dataset Information

0

Whole genome sequencing of multiple myeloma identifies novel structural and non-coding mutations.


ABSTRACT: The coding region of the myeloma genome is well understood with key mutations having been identified. However, the non-coding regions of the myeloma genome are yet to be analyzed. Here we have performed whole genome sequencing of myeloma patient samples to identify structural abnormalities including chromothripsis and chromoplexy, as well as gene dysregulation through super-enhancer juxtaposition with key oncogenes. We have also identified non-coding region hotspots of mutation, especially in promoter regions, that affect gene expression.

PROVIDER: EGAS00001003164 | EGA |

REPOSITORIES: EGA

Similar Datasets

2014-04-17 | E-GEOD-56872 | biostudies-arrayexpress
2014-04-17 | GSE56872 | GEO
2015-09-15 | E-GEOD-71596 | biostudies-arrayexpress
2020-01-29 | PXD017309 | Pride
| EGAS00001002872 | EGA
2020-04-09 | GSE148303 | GEO
2020-07-21 | PXD019169 | Pride
2015-09-15 | GSE71596 | GEO
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
2017-06-02 | GSE93916 | GEO