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Tumor intrinsic and extrinsic mechanisms of response and resistance to blinatumomab in relapsed/refractory acute lymphoblastic leukemia

ABSTRACT: Key PointsÃ¢Â€Â¢ Multiple mechanisms of acquired CD19 mutations and splicing contribute to CD19 loss and relapse to blinatumomab.Ã¢Â€Â¢ Identification of CD19 ex2part levels represents a new biomarker predictive of resistance or likely failure of blinatumomab

PROVIDER: EGAS00001004027 | EGA |

REPOSITORIES: EGA

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