Genomics

Dataset Information

0

Nuclease deficiencies alter plasma cell-free DNA methylationprofiles (Human)


ABSTRACT: The effects of DNASE1L3 or DNASE1 deficiency on cfDNA methylation was explored in plasma of mice deficient in these nucleases and in DNASE1L3-deficient humans. Compared to wildtype cfDNA, cfDNA in Dnase1l3-deficient mice was significantly hypomethylated, while cfDNA in Dnase1-deficient mice was hypermethylated. The cfDNA hypomethylation in Dnase1l3-deficient mice was due to increased fragmentation and representation from open chromatin regions (OCRs) and CpG islands (CGIs). These findings were absent in Dnase1-deficient mice.

PROVIDER: EGAS00001004897 | EGA |

REPOSITORIES: EGA

Similar Datasets

| EGAS00001004696 | EGA
| EGAD00001007751 | EGA
2020-10-29 | E-MTAB-9678 | biostudies-arrayexpress
2010-06-20 | E-GEOD-15552 | biostudies-arrayexpress
2009-04-04 | GSE15552 | GEO
2014-06-04 | E-GEOD-44036 | biostudies-arrayexpress
2014-06-04 | E-GEOD-49833 | biostudies-arrayexpress
2014-06-04 | GSE50016 | GEO
2014-06-04 | GSE49833 | GEO
2014-06-04 | GSE44038 | GEO