Genomics

Dataset Information

0

Endothelium-derived stromal cells contribute to bone marrow niche formation


ABSTRACT: Comprehensive transcriptional characterization of bone marrow stromal cells by RNA sequencing was performed to determine the molecular properties/signatures of endothelium during niche formation.Here, we identify a rare subset of cells in the human fetal BM that co-express endothelial and stromal markers, including low-affinity nerve growth factor receptor (LNGFR/CD271). They display transcriptional reprogramming consistent with endothelial-to-mesenchymal transition (EndoMT), reflected in their potential to generate stromal cells with in vivo BM niche forming capacity.

PROVIDER: EGAS00001004946 | EGA |

REPOSITORIES: EGA

Similar Datasets

2022-03-08 | GSE198049 | GEO
2023-04-14 | GSE227147 | GEO
2023-04-14 | GSE227143 | GEO
2023-04-14 | GSE227144 | GEO
2015-11-04 | GSE61636 | GEO
2023-04-14 | GSE227145 | GEO
2023-04-14 | GSE227146 | GEO
2015-11-04 | E-GEOD-61636 | biostudies-arrayexpress
2015-08-01 | E-GEOD-71288 | biostudies-arrayexpress
2015-08-01 | GSE71288 | GEO