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Whole-exome sequencing of hepatocellular carcinoma biopsies (proteogenomic study)

ABSTRACT: We performed a proteogenomic analysis of hepatocellular carcinomas (HCCs) across clinical stages and etiologies to define the deregulated pathways and heterogeneity among HCCs. We identified pathways that are differentially regulated on the genomic, transcriptomic, proteomic and phosphoproteomic levels. Integrative clustering identified HCC subgroups that show distinct regulation of biological processes, metabolic reprogramming and kinase activation.

PROVIDER: EGAS00001005073 | EGA |

REPOSITORIES: EGA

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