Genomics

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G-SAM: Transcriptional Evolution of Glioblastomas Treated With Standard of Care

ABSTRACT: Collection of mostly matching primary and recurrent glioblastoma RNA-seq sample pairs, also matching with an earlier DNA sequencing study

PROVIDER: EGAS00001005436 | EGA |

REPOSITORIES: EGA

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Publications

Molecular Evolution of <i>IDH</i> Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study.

Draaisma Kaspar K   Chatzipli Aikaterini A   Taphoorn Martin M   Kerkhof Melissa M   Weyerbrock Astrid A   Sanson Marc M   Hoeben Ann A   Lukacova Slávka S   Lombardi Giuseppe G   Leenstra Sieger S   Hanse Monique M   Fleischeuer Ruth R   Watts Colin C   McAbee Joseph J   Angelopoulos Nicos N   Gorlia Thierry T   Golfinopoulos Vassilis V   Kros Johan M JM   Verhaak Roel G W RGW   Bours Vincent V   van den Bent Martin J MJ   McDermott Ultan U   Robe Pierre A PA   French Pim J PJ  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20191119 1

<h4>Purpose</h4>Precision medicine trials in glioblastoma (GBM) are often conducted at tumor recurrence. However, second surgeries for recurrent GBM are not routinely performed, and therefore, molecular data for trial inclusion are predominantly derived from the primary sample. This study aims to establish whether molecular targets change during tumor progression and, if so, whether this affects precision medicine trial design.<h4>Materials and methods</h4>We collected 186 pairs of primary-recur  ...[more]

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