Genomics

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Mapping genetic effects on cell type-specific chromatin accessibility using single nucleus ATAC-seq


ABSTRACT: Gene regulation is highly cell type-specific and understanding the function of non-coding genetic variants associated with complex traits requires molecular phenotyping at cell type resolution. In this study we performed single nucleus ATAC-seq (snATAC-seq) and genotyping in peripheral blood mononuclear cells from 13 individuals. We mapped chromatin accessibility QTLs (caQTLs) in each immune cell type and sub-type in a subset of 10 samples of European genetic ancestry.

PROVIDER: EGAS00001006184 | EGA |

REPOSITORIES: EGA

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