Genomics

Dataset Information

0

Molecular characterization of a renal cell carcinoma PDX cohort


ABSTRACT: Patient-derived xenograft (PDX) models represent an essential tool for the preclinical evaluation of novel targeted therapies and their combinations. In this project, we molecularly characterized a comprehensive panel of RCC PDX models with well conserved molecular and pathological features over multiple passages. PDX samples were subjected to next generation sequencing (NGS). Characterization of cancer-relevant features including driver mutations or cellular processes was performed using mutational and gene expression data in order to identify potential biomarker or treatment targets in RCC. In summary, we reported a newly established and molecularly characterized panel of RCC PDX models with high relevance for translational preclinical research.

PROVIDER: EGAS00001006249 | EGA |

REPOSITORIES: EGA

Similar Datasets

2016-06-29 | E-GEOD-83820 | biostudies-arrayexpress
| EGAS00001007119 | EGA
2016-06-29 | GSE83820 | GEO
2019-08-27 | E-MTAB-7568 | biostudies-arrayexpress
2022-02-17 | PXD027419 | Pride
2023-07-18 | GSE235167 | GEO
2021-10-27 | GSE180790 | GEO
2024-09-30 | GSE276609 | GEO
2023-07-18 | GSE235168 | GEO
2020-07-29 | GSE155262 | GEO