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Study of the microenvironment of angioimmunoblastic T-cell lymphoma

ABSTRACT: Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes development of T follicular helper-like tumor cells. We investigated the mechanism by which TET2-mutant immune cells enable AITL development. Single-cell RNA-sequencing of human AITL samples revealed significant expansion of aberrant B cells. The genes expressed in aberrantly expanded GCB cells in murine tumors were also broadly expressed in the B-lineage cells of TET2-mutant human AITL.

PROVIDER: EGAS00001006401 | EGA |

REPOSITORIES: EGA

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