Genomics

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A machine learning classifier for DNA repair defects using plasma DNA


ABSTRACT: We present DARC Sign (DnA Repair Classification SIGNatures); a public machine learning tool leveraging clinically-practical liquid biopsy specimens for simultaneously identifying multiple types of metastatic prostate cancer DDR deficiencies. We posit that it will be useful for understanding differential responses to DDR-directed therapies in ongoing clinical trials and may ultimately enable prospective identification of prostate cancers with phenotypic evidence of DDR deficiency.

PROVIDER: EGAS00001007006 | EGA |

REPOSITORIES: EGA

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