Dataset Information
Genome-Wide Association Study of Preterm Birth
Ontology highlight
ABSTRACT: Preterm birth (PTB, born before 37 weeks of gestation) accounts for 12.5% of all births in the U.S. It is a leading cause of neonatal mortality and post-natal morbidity. The highest rate of PTB occurs among the black population (17.8%). Available literature and our research findings strongly suggest that genetic factors play an important role in PTB. Supported by a grant from the NICHD, the goal of this project is to conduct a genome-wide association (GWA) study and apply advanced statistical methods to identify susceptibility loci of PTB. We will genotype 1,000 black mothers who delivered preterm births (cases) and 1,000 age-matched black mothers who delivered term births (controls) at the Boston Medical Center (BMC), using the Illumina HumanOmni 2.5 array. Subsequently, we will perform replication analysis of the SNPs using independent, multi-ethnic samples from the BMC. We also will genotype the significant single-nucleotide polymorphisms (SNPs) in babies born to the study mothers, and examine if the fetal gene interacts with the maternal gene to affect the risk of PTB. PUBLIC HEALTH REVELANCE: We anticipate that this study will lead to the identification of novel genetic loci of PTB. Such findings not only will provide important insights into mechanisms leading to PTB, but also may help identify women at high-risk of PTB, which in turn, may lead to the development of early and targeted interventions that can prevent PTB or mitigate the severity and consequences of PTB.
PROVIDER: phs000332.v1.p1 | EGA |
REPOSITORIES: EGA
Publications
Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study.
Pediatrics 20100322 4
<h4>Objective</h4>We sought to determine whether placental markers of intrauterine inflammation were associated with poor weight gain among premature infants in the neonatal period.<h4>Methods</h4>We reviewed 697 preterm births prospectively enrolled as part of an ongoing molecular epidemiological study. Placental markers and serial weight gain were analyzed for premature infants who were hospitalized for >/=21 days (N = 256). Placentas were examined for maternal inflammatory response (MIR), def ...[more]
