Ontology highlight
ABSTRACT: Comprehensive knowledge about the spatiotemporal dynamics of the brain transcriptome is essential for a better understanding of neurodevelopment, sexual dimorphism, and evolution, as well as our increased susceptibility to certain brain disorders. We generated and analyzed genome-wide exon-level transcriptome data from 16 brain regions of 57 postmortem human brains, spanning from embryonic development to late adulthood and representing males and females of multiple ethnicities. We also performed genome-wide genotyping of 2.5 million SNPs and assessed genome normality for all donors. This study provides a comprehensive, publicly available dataset on the spatiotemporal human brain transcriptome and new insights into the transcriptional foundations of human neurodevelopment.
OTHER RELATED OMICS DATASETS IN: PRJNA134455
PROVIDER: phs000406.v1.p1 | EGA |
REPOSITORIES: EGA
Kang Hyo Jung HJ Kawasawa Yuka Imamura YI Cheng Feng F Zhu Ying Y Xu Xuming X Li Mingfeng M Sousa André M M AM Pletikos Mihovil M Meyer Kyle A KA Sedmak Goran G Guennel Tobias T Shin Yurae Y Johnson Matthew B MB Krsnik Zeljka Z Mayer Simone S Fertuzinhos Sofia S Umlauf Sheila S Lisgo Steven N SN Vortmeyer Alexander A Weinberger Daniel R DR Mane Shrikant S Hyde Thomas M TM Huttner Anita A Reimers Mark M Kleinman Joel E JE Sestan Nenad N
Nature 20111026 7370
Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains. We found that 86 per cent of the genes anal ...[more]