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Association of GDNF gene variants with tobacco and betel quid chewing in ethnic groups from India

ABSTRACT: An association study of GDNF polymorphisms with tobacco and betel quid use in Indian populations

INSTRUMENT(S): -

ORGANISM(S): Homo Sapiens

SUBMITTER: Semmelweis University

PROVIDER: PRJEB56398 | EVA | 2022-10-03

REPOSITORIES: EVA

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			Action	DRS
	GDNF_in_tobacco_betel_DAS_et_al_#613343.vcf.csi	Other
	GDNF_in_tobacco_betel_DAS_et_al_#613343.vcf.gz	Vcf
	GDNF_in_tobacco_betel_DAS_et_al_#613343.vcf.gz.csi	Vcf

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Project description:BACKGROUND: Metagenomic studies carried out in the past decade have led to an enhanced understanding of the gut microbiome in human health, however, the Indian gut microbiome is not well explored yet. We analysed the gut microbiome of 110 healthy individuals from two distinct locations (North-Central and Southern) in India using multi-omics approaches, including 16S rRNA gene amplicon sequencing, whole genome shotgun metagenomic sequencing, and metabolomic profiling of faecal and serum samples. </br> RESULTS: The gene catalogue established in this study emphasizes the uniqueness of the Indian gut microbiome in comparison to other populations. The gut microbiome of the cohort from North-Central India, which was primarily consuming a plant-based diet, was found to be associated with Prevotella, and also showed an enrichment of Branched Chain Amino Acid (BCAA) and lipopolysaccharide (LPS) biosynthesis pathways. In contrast, the gut microbiome of the cohort from Southern India, which was consuming an omnivorous diet, showed associations with Bacteroides, Ruminococcus and Faecalibacterium, and had an enrichment of Short Chain Fatty Acid (SCFA) biosynthesis pathway and BCAA transporters. This corroborated well with the metabolomics results, which showed higher concentration of BCAAs in the serum metabolome of the North-Central cohort and an association with Prevotella. In contrast, the concentration of BCAAs were found higher in the faecal metabolome of the Southern-India cohort, and showed a positive correlation with the higher abundance of BCAA transporters. </br> CONCLUSIONS: The study reveals the unique composition of Indian gut microbiome, establishes the Indian gut microbial gene catalogue, and compares it with the gut microbiome of other populations. The functional associations revealed using metagenomic and metabolomic approaches provide novel insights on the gut-microbe-metabolic axis, which will be useful for future epidemiological and translational researches.

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Association of GDNF gene variants with tobacco and betel quid chewing in ethnic groups from India

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