Dataset Information
BIOMD0000000005 from BioModels Database
Ontology highlight
ABSTRACT:
SUBMITTER: Ron Henkel
PROVIDER: 196 | FAIRDOMHub | 2019-12-16
REPOSITORIES: FAIRDOMHub
Publications
Modeling the cell division cycle: cdc2 and cyclin interactions.
Proceedings of the National Academy of Sciences of the United States of America 19910801 16
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the s ...[more]