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A Mathematical Model of Metabolism and Regulation Provides a Systems-Level View of the Oxygen Response of Escherichia coli

ABSTRACT: A Mathematical Model of Metabolism and Regulation Provides a Systems-Level View of the Oxygen Response of Escherichia coli

SUBMITTER: Michael Ederer

PROVIDER: 23 | FAIRDOMHub | 2014-03-18

REPOSITORIES: FAIRDOMHub

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A mathematical model of metabolism and regulation provides a systems-level view of how Escherichia coli responds to oxygen.

Ederer Michael M Steinsiek Sonja S Stagge Stefan S Rolfe Matthew D MD Ter Beek Alexander A Knies David D Teixeira de Mattos M Joost MJ Sauter Thomas T Green Jeffrey J Poole Robert K RK Bettenbrock Katja K Sawodny Oliver O

Frontiers in microbiology 20140327

The efficient redesign of bacteria for biotechnological purposes, such as biofuel production, waste disposal or specific biocatalytic functions, requires a quantitative systems-level understanding of energy supply, carbon, and redox metabolism. The measurement of transcript levels, metabolite concentrations and metabolic fluxes per se gives an incomplete picture. An appreciation of the interdependencies between the different measurement values is essential for systems-level understanding. Mathem ...[more]

PMID: 24723921

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