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RNA sequencing analysis of the Lewis versus Brown Norway rat, with or without Toxoplasma gondii infection

ABSTRACT: Rats vary in their susceptibilities to Toxoplasma gondii infection depending on the rat strain. Compared to the T. gondii-susceptible Brown Norway (BN) rat, the Lewis (LEW) rat is extremely resistant to T. gondii. Thus, these two rat strains are ideal models for elucidating host mechanisms that are important for host resistance to T. gondii infection. Therefore, in an attempt to unravel molecular factors directing the protective early innate immune responses in the LEW rat, we performed RNA sequencing analysis of the LEW versus BN rat, with or without T. gondii infection.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE100203 | GEO | 2017/07/24

SECONDARY ACCESSION(S): PRJNA390980

REPOSITORIES: GEO

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