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High-Resolution temporal profiling of developing pancreas uncovers the mechanisms of endocrine cell fate determination [ATAC-Seq]

ABSTRACT: Chromatin accessibility of endocrine progenitor cells from the e14.5 and e16.5 mouse pancreas

ORGANISM(S): Mus musculus

PROVIDER: GSE100621 | GEO | 2018/06/05

REPOSITORIES: GEO

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High-Resolution temporal profiling of developing pancreas uncovers the mechanisms of endocrine cell fate determination [Drop-seq]

Project description:Drop-sequencing of the whole e14.5 and e16.5 mouse pancreas

2018-06-05 | GSE100619 | GEO

High-Resolution temporal profiling of developing pancreas uncovers the mechanisms of endocrine cell fate determination [MATQ-seq]

Project description:MATQ-sequencing of single isolated endocrine progenitors (EPs) from the e14.5 and e16.5 mouse pancreas

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High-Resolution temporal profiling of developing pancreas uncovers the mechanisms of endocrine cell fate determination

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-05 | GSE100622 | GEO

High-Resolution temporal profiling of developing pancreas uncovers the mechanisms of endocrine cell fate determination

Project description:High-Resolution temporal profiling of developing pancreas uncovers the mechanisms of endocrine cell fate determination

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Expression profiling of pancreas development

Project description:Development of the pancreas from the endoderm is initiated at embryonic day 9 of mouse development and over the following days several different cell types develop from pancreas progenitor cells. A distinct phase of pancreas development, known as the secondary transition, is initiated at day 13 of development and one of the key features of this transition is a massive increase in the number of mature endocrine cells. To study gene expression in pancreas during the secondary transition we performed high-density oligonucleotide microarray experiments on dorsal pancreas tissue isolated from NMRI embryos on consecutive days from e12.5 to e16.5. Keywords: time course

2007-06-09 | GSE8070 | GEO

EphB3 marks delaminating endocrine progenitor cells in the developing pancreas.

Project description:BackgroundUnderstanding the process by which pancreatic beta-cells acquire their "fate" is critical to the development of in vitro directed differentiation protocols for cell replacement therapies for diabetics. To date, these efforts are hampered by a paucity of markers that distinguish pancreatic endocrine cells at different stages of differentiation.ResultsHere, we identify EphB3 as a novel pro-endocrine marker and use its expression to track delaminating islet lineages. First, we provide a detailed developmental expression profile for EphB3 and other EphB family members in the embryonic pancreas. We demonstrate that EphB3 transiently marks endocrine cells as they delaminate from the pancreatic epithelium, prior to their differentiation. Using a Tet-inducible EphB3(rtTA-lacZ) reporter line, we show that short-term pulse-labeled EphB3(+) cells co-express Pdx1, Nkx6.1, Ngn3, and Synaptophysin, but not insulin, glucagon, or other endocrine hormones. Prolonged labeling tracks EphB3(+) cells from their exit from the epithelium to their differentiation.ConclusionsThese studies demonstrate that pro-endocrine cell differentiation during late gestation, from delamination to maturation, takes approximately 2 days. Together, these data introduce EphB3 as a new biomarker to identify beta-cells at a critical step during their step-wise differentiation and define the timeframe of endocrine differentiation.

| S-EPMC3328632 | biostudies-literature

Gene expression analysis of reprogrammed pancreatic cells, liver and pancreas

Project description:We recently generated pancreatic progenitor cells (so-called TiPP cells, TGIF2-induced pancreatic progenitors) by reprogramming adult hepatic cells (HEP). To analyze the extent of reprogramming and to investigate the mechanisms underlying liver-to-pancreas conversion, we analyzed the changes in gene expression in TiPP cells at two time points (day 14 and day 30 after transduction) compared to control HEP cells, mouse embryonic pancreas (E14.5) and adult pancreas and liver tissues.

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TF ChIP-seq from progenitor cell of endocrine pancreas (ENCSR901NIN)

Project description:CTCF ChIP-seq on progenitor cell of endocrine pancreas originated from progenitor cell of endocrine pancreas For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

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Control ChIP-seq from progenitor cell of endocrine pancreas (ENCSR077RBB)

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